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内容编辑Stat1敲除小鼠
分类: 免疫肿瘤鼠
发布时间: 2019-09-26 11:00
应用：凋亡
级别：SPF
类型：KO
背景：C57BL/6
名称：Stat1-KO
编号：LM000156
级别：SPF
类型：KO
背景：C57BL/6
名称：Stat1-KO
编号：LM000156
使用基因编缉技术删除Stat1基因exons，建立Stat1基因敲除小鼠模型。信号转导子和转录激活子（signal transducer and activator of transcription，STAT）是酪氨酸激酶（Janus kinase，JAK）-STAT信号传递途径中的重要环节，通过这一途径细胞信号可以从细胞外传递到细胞内，使相关基因活化，实现对细胞生长、分化等机能的调控。STAT1能够促凋亡、抑制细胞生长、分化，在抑制肿瘤的发生、发展中发挥重要作用。
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