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内容编辑hPCSK9人源化小鼠
分类: 心血管疾病鼠
发布时间: 2019-09-09 11:00
应用：高血脂症
级别：SPF
类型：Hu
背景：C57BL/6
名称：hPCSK9
编号：LM000173
级别：SPF
类型：Hu
背景：C57BL/6
名称：hPCSK9
编号：LM000173
使用基因编辑技术将小鼠PCSK9基因的编码区进行了人源化替换，构建了B6-hPCSK9人源化小鼠。在普通饲料下肝脏中LDLR水平以及血液中LDL-C水平没有显著的改变，经高胆固醇饲料喂养后可发生高血脂症。Proprotein convertase subtilisin/kexin type 9 (PCSK9) 是已知的一种对LDLR在细胞膜上的表达水平起负调控作用的细胞分泌因子，可通过促进LDLR的降解，降低肝细胞对胞外LDL-C的回收。
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